Top-Rated Hypoallergenic Bed Sheets 2025 - 10 Best Picks

Soft, hypoallergenic, and stain-resistant queen-sized bed sheet set by Serta.

The Serta Simply Clean Super Soft Hypoallergenic Stain Resistant Deep Pocket 4 Pieces Solid Bed Sheet Set is a high-quality, grey queen-sized bed sheet set. It is designed to be incredibly soft, hypoallergenic, and resistant to stains, making it perfect for individuals with sensitive skin or allergies. The set includes one fitted sheet, one flat sheet, and two pillowcases.

Threadmill 100% Cotton Hypoallergenic/Breathable/Stain-Resistant, 500 Thread Count, Solid 4-Piece Be

Amazon product: Threadmill 100% Cotton Hypoallergenic/Breathable/Stain-Resistant, 500 Thread Count, Solid 4-Piece Bed Sheet Set (1 Flat, 1 Fitted Sheet, 2 Pillow Covers), Queen White Sheets Set

Eucalyptus sheets infused with silver for a cooler, softer, and odor-free sleep experience.

These CASILVA sheets are made from 100% Tencel Lyocell, a eucalyptus-based fiber that's softer than silk and cooler than cotton. They are infused with silver to provide anti-odor properties, making them perfect for hot sleepers and individuals with sensitive skin.

Soft, hypoallergenic, stain-resistant 4-piece king bed sheet set from Serta.

This is a super soft, hypoallergenic, stain-resistant sheet set from Serta. It includes 4 pieces: a fitted sheet, a flat sheet, and two pillowcases. The sheets are deep pocketed to fit large mattresses and are made with a solid white design.

Extra deep, breathable and hypoallergenic queen sheet set for a luxurious sleep experience.

This 6-piece luxurious queen sheet set is designed with extra deep pockets to securely fit even the thickest mattresses. It's made with breathable, hypoallergenic material that's wrinkle-free for a comfy and clean sleep. This off-white sheet set is crafted to provide hotel-like luxury right at home.

Luxury bamboo sheets designed for comfort and cool sleeping.

The Bella Coterie Bamboo Queen Sheets are made from 100% organically grown bamboo viscose, offering ultra-soft comfort and cooling properties for hot sleepers. The set includes a fitted sheet with an 18-inch deep pocket, perfect for larger mattresses, and comes in a calming ivory color.

Queen-sized, GOTS-certified, organic cotton sheets for comfortable and eco-friendly bedding.

The Mayfair Linen 100% Organic Cotton Sheets set includes four pieces of queen size, white, percale sheets that are soft, cooling, and breathable. The sheets have a 16-inch deep pocket, suitable for most mattresses, and are certified by the Global Organic Textile Standard (GOTS).

Super soft, easy-care microfiber queen bedsheet set in frosted lavender from Amazon Basics.

This is a four-piece queen-size bedsheet set from Amazon Basics, which includes a flat sheet, a fitted sheet, and two pillowcases. The material is lightweight, super soft, and easy-care microfiber with 14-inch deep pockets, and it comes in a stylish frosted lavender color.

LuxClub's luxurious, eco-friendly and breathable bamboo queen-sized sheets.

The LuxClub Bamboo Queen Sheets are made from 100% viscose derived from bamboo, providing a cooling, breathable sleep experience. These deep pocket sheets can accommodate mattresses up to 16 inches, delivering hotel luxury comfort in your own home.

Eucalyptus Lyocell Bed Sheets, Hypoallergenic 100% Organic Tencel, Thermal Regulating and Moisture W

Amazon product: Eucalyptus Lyocell Bed Sheets, Hypoallergenic 100% Organic Tencel, Thermal Regulating and Moisture Wicking for Hot Sleepers, Superior Thread Quality, Extra Deep Pockets Queen Size - White