2025 Best Mood Support Supplements - Data-Driven Reviews of 10 Products

Natural mood support supplement with a potent blend of herbs and extracts.

A powerful blend of saffron extract, ashwagandha, L-theanine, Ginkgo Biloba, St. John's Wort, Rhodiola Rosea, and 5-HTP, aiming to support emotional health and mood balance. Clean Nutraceuticals' advanced formula promises to provide natural stress relief, mood enhancement, and cognitive function improvement.

A natural mood-supporting probiotic with stress-relieving and digestive health benefits.

A natural supplement designed to support a balanced mood, healthy stress response, and digestive health. It is enriched with prebiotics, Ashwagandha, Vitamin B12, and Folate, which are known for their mood-enhancing and stress-relieving properties. This product is formulated for both men and women.

Natural supplement for stress relief, relaxation, mental clarity, and sleep support.

A powerful blend of 28 natural ingredients designed to relieve occasional stress and anxious feelings, promote relaxation, and enhance mental clarity. It also aids in achieving maximum sleep, making it an ideal mood and sleep support for both men and women. The supplement comes in a pack of 120 vegan capsules.

Digestive and mood support supplement with clinically studied probiotic strains.

This is a mood-boosting supplement from InnovixLabs, primarily designed to support digestive health and enhance mood. It contains two clinically studied strains of probiotics - Lactobacillus helveticus Rosell-52ND and Bifidobacterium longum Rosell-175 - to help with mood regulation, stress management, and overall gut health.

Natural cortisol supplement for stress relief and mood enhancement.

These capsules are a cortisol supplement designed for both men and women, containing a blend of natural ingredients including Bacopa Monnieri, Lemon Balm, Ashwagandha, 5-HTP, GABA, and L-Theanine. The product aims to support stress relief and mood enhancement, serving as a nerve calmant for adults.

Natural mood enhancer and stress reducer, promoting relaxation and improved sleep.

ONNIT New Mood Daily Stress Support is a dietary supplement designed to enhance mood and reduce stress. The product is IGEN™ Non-GMO Tested and aims to provide a natural serotonin boost, promoting relaxation and better sleep quality. It's a popular choice for both men and women, with a 30 capsule count per bottle.

Mood-enhancing, stress-managing probiotic supplement with organic ashwagandha.

This is a probiotic supplement formulated by Dr. Perlmutter, a renowned neurologist, that promotes emotional well-being and digestive balance. It contains 16 strains of probiotics, including L. acidophilus and B. lactis, and 50 billion CFU, along with organic ashwagandha and Alaskan blueberries for stress management.

Natural supplement for stress relief and mood support featuring Ashwagandha, Kava Kava, GABA, and L-Theanine.

LifeSeasons Anxie-T is a natural supplement formulated to support mood and mental focus, ease tension and nervousness, and help users feel calm and relaxed. The product features a blend of potent ingredients including Ashwagandha, Kava Kava, GABA, and L-Theanine, which are known for their stress-relieving properties.

Plant-based mood enhancer and stress reliever with a complex of 7 herbs.

The Joy-Filled Mood Support Supplement is a 100% plant-based formula containing a 7-herb complex including St. John’s Wort, Ashwagandha, and Rhodiola Rosea. It is designed to help calm the mind and body, providing stress relief and enhancing mood.

Non-GMO, vegetarian mood support supplement with Ashwagandha, Rhodiola, St. John’s Wort, and L-Theanine.

Futurebiotics Chill Pill is an all-natural mood support supplement that includes Ashwagandha, Rhodiola, St. John’s Wort, and L-Theanine. These 120 non-GMO, vegetarian tablets are designed to help reduce stress and anxiety, promoting a calm, relaxed mood.